Editing Serimmune antibody analysis results

Jump to navigation Jump to search

Warning: You are not logged in. Your IP address will be publicly visible if you make any edits. If you log in or create an account, your edits will be attributed to your username, along with other benefits.

The edit can be undone. Please check the comparison below to verify that this is what you want to do, and then save the changes below to finish undoing the edit.

Latest revision Your text
Line 1: Line 1:
−
{{Project Infobox|Self researchers=User:Madprime,User:Sprague |Related tools= |Related topics= }}
 
−
 
 
[[File:Serimmunetypicalresults.png|alt=image of a sample result|thumb|Serimmune antibody test results sample.]]
 
[[File:Serimmunetypicalresults.png|alt=image of a sample result|thumb|Serimmune antibody test results sample.]]
 
The [https://serimmune.com/covid19study/ Serimmune COVID-19 Study] is a longitudinal research study conducted by the Serimmune company. The study uses the company's "Serum Epitope Repertoire Analysis (SERA) technology" to study antibody responses, especially in the context of COVID-19 vaccination and exposure.
 
The [https://serimmune.com/covid19study/ Serimmune COVID-19 Study] is a longitudinal research study conducted by the Serimmune company. The study uses the company's "Serum Epitope Repertoire Analysis (SERA) technology" to study antibody responses, especially in the context of COVID-19 vaccination and exposure.
  
−
 
+
The company pre-published<ref>High-resolution mapping and characterization of epitopes in COVID-19 patients
−
The study returns research-grade results (not intended for diagnostic clinical use) to participants. As described in the [https://serimmune.com/caspio-content/COVID-19-Study-Consent-Form-and-Bill-of-Rights-Preview.pdf study consent document], these results are not clinically validated and not meant to serve as a clinical assay. They are, nevertheless, interesting to look at!
 
−
 
 
−
The study is planned to last five years, with blood samples collected every six months. Samples are self-collected by participants using a home collection kit and sent by mail.
 
−
 
 
−
= How Serimmune's Technology Works =
 
−
 
 
−
 
 
−
According to the company's pre-published<ref>High-resolution mapping and characterization of epitopes in COVID-19 patients
 
  
 
Winston A. Haynes, Kathy Kamath, Joel Bozekowski, Elisabeth Baum-Jones, Melissa Campbell, Arnau Casanovas-Massana, Patrick S. Daugherty, Charles S. Dela Cruz, Abhilash Dhal, Shelli F. Farhadian, Lynn Fitzgibbons, John Fournier, Michael Jhatro, Gregory Jordan, Debra Kessler, Jon Klein, Carolina Lucas, Larry L. Luchsinger, Brian Martinez, Mary C. Muenker, Lauren Pischel, Jack Reifert, Jaymie R. Sawyer, Rebecca Waitz, Elsio A. Wunder Jr., Minlu Zhang, Yale IMPACT Team, Akiko Iwasaki, Albert I. Ko, John C. Shon
 
Winston A. Haynes, Kathy Kamath, Joel Bozekowski, Elisabeth Baum-Jones, Melissa Campbell, Arnau Casanovas-Massana, Patrick S. Daugherty, Charles S. Dela Cruz, Abhilash Dhal, Shelli F. Farhadian, Lynn Fitzgibbons, John Fournier, Michael Jhatro, Gregory Jordan, Debra Kessler, Jon Klein, Carolina Lucas, Larry L. Luchsinger, Brian Martinez, Mary C. Muenker, Lauren Pischel, Jack Reifert, Jaymie R. Sawyer, Rebecca Waitz, Elsio A. Wunder Jr., Minlu Zhang, Yale IMPACT Team, Akiko Iwasaki, Albert I. Ko, John C. Shon
  
−
medRxiv 2020.11.23.20235002; doi: <nowiki>https://doi.org/10.1101/2020.11.23.20235002</nowiki></ref> research, the technology uses a combination of biochemical assays and a machine learning-based analytics pipeline.
+
medRxiv 2020.11.23.20235002; doi: <nowiki>https://doi.org/10.1101/2020.11.23.20235002</nowiki></ref> the technical details behind their platform.
  
−
First, they chemically break a blood sample into one million molecules they call the "epitope repertoire". Roughly speaking, this is an approximation of possible ways that antibodies can bond in this individual.
+
The study returns research-grade results (not intended for diagnostic clinical use) to participants. As described in the [https://serimmune.com/caspio-content/COVID-19-Study-Consent-Form-and-Bill-of-Rights-Preview.pdf study consent document], these results are not clinically validated and not meant to serve as a clinical assay. They are, nevertheless, interesting to look at!
  
−
Next, they compare this individual's epitope with others taken from people with known exposure to specific infections. Theoretically, this is a map to those molecules associated with a particular pathogen. Using a machine learning algorithm trained on epitopes from known infections, the company generates a report to indicate the similarity with this person's epitope.
+
The study is planned to last five years, with blood samples collected every six months. Samples are self-collected by participants using a home collection kit and sent by mail.
  
−
The gold standard for antibody measurement is a complex process called ELISA (enzyme-linked immunosorbent assay) that involves smudging a bit of sample onto a specially-prepared plate full of proteins known to be associated with the disease. The plate is designed to change color if an antibody to the disease happens to match whatever’s on the plate.
+
{{Project Infobox|Self researchers=User:Madprime,User:Sprague |Related tools= |Related topics= }}
  
−
Serimmune claims their test works very well compared to ELISA. It has a high “specificity” (true negative): when they say a sample doesn’t have COVID, they’re almost always right. In fact, when they applied their test to samples taken before the pandemic, every single time they correctly ruled out COVID.
+
=SARS-CoV-2 Antibody Analyses=
  
−
=SARS-CoV-2 Sample Reports =
+
==Vaccine-only responses==
  
−
[[File:Before_and_after_covid_antibody_results.png|alt=image of results before (one test) and after (two tests) covid infection|thumb|Serimmune results before and after natural covid infection in a previously-vaccinated individual.]]
+
{| class="wikitable"
−
 
 
−
{| class="wikitable sortable"
 
 
|-
 
|-
−
! Individual
+
! Individual !! Date !! Report !! Notes
−
! Date
 
−
! class=unsortable| Report
 
−
! Vaccination
 
−
! Natural infection
 
−
! class=unsortable| Notes
 
 
|-
 
|-
−
| [[User:Sprague]] || 2021-12-14 || [[File:RichardSpragueSerimmuneCOVID 20211214.pdf]] || Pfizer || No || Pfizer vaccine (two shots, no booster)
+
| [[User:Madprime]] || 2022-02-03 || [[File:TOEAIX_20220203.pdf]] || Moderna vaccine (two shots, plus booster)
 
|-
 
|-
−
| [[User:Madprime]] || 2022-02-03 || [[File:TOEAIX_20220203.pdf]] || Moderna || No || Moderna vaccine (two shots, plus booster).
+
| [[User:Sprague]] || |2021-12-14 || [[File:RichardSpragueSerimmuneCOVID 20211214.pdf]] || Pfizer vaccine (two shots, no booster)
 
|-
 
|-
−
| [[User:Madprime]] || 2022-05-27 || [[File:TOEAIX_20220527.pdf]] || Moderna || Yes || Covid positive on 2022-05-01.
+
| [[User:Igerg]] || 2022-04-13 || [[File:EXACZL_20220413.pdf]] || Moderna vaccine (two shots, plus booster) - chronic spontaneous urticaria following booster
 +
|}
 +
 
 +
==Post-exposure responses==
 +
 
 +
[[File:Before_and_after_covid_antibody_results.png|alt=image of results before and after covid infection|thumb|Serimmune results before and after natural covid infection in a previously-vaccinated individual.]]
 +
 
 +
{| class="wikitable"
 
|-
 
|-
−
| [[User:Madprime]] || 2022-08-04 || [[File:TOEAIX_20220804.pdf]] || Moderna || Yes || No additional history.
+
! Individual !! Date !! Report !! Notes
 
|-
 
|-
−
| [[User:Igerg]] || 2022-04-13 || [[File:EXACZL_20220413.pdf]] || Moderna || No || Moderna vaccine (two shots, plus booster) - chronic spontaneous urticaria following booster
+
| [[ User:Madprime]] || 2022-05-27 || [[File:TOEAIX_20220527.pdf]] || Covid positive on 2022-05-01. Previously vaccinated with booster.
−
|-
 
−
| [[User:EricJain]] || 2022-07-21 || [[File:EricJain-Serimmune-20220721.pdf]] || Pfizer || No || Report includes comparison to 2022-01-20. Vaccinations: 2021-04-21 (Pfizer), 2021-05-12 (Pfizer), 2021-12-08 (Pfizer).
 
 
|}
 
|}
−
 
  
 
= Other results=
 
= Other results=
Line 60: Line 47:
 
|-
 
|-
 
!Individual!!Date!!Report!!Notes
 
!Individual!!Date!!Report!!Notes
 +
|-
 +
| [[User:Madprime]]||2022-02-03||[[File:TOEAIX_Expanded_20220203.pdf]]||No medical history related to these analyses.
 
|-
 
|-
 
| [[User:Sprague]] || 2021-12-14 ||[[File:RichardSpragueSerimmune_20211214.pdf]] ||
 
| [[User:Sprague]] || 2021-12-14 ||[[File:RichardSpragueSerimmune_20211214.pdf]] ||
−
|-
 
−
| [[User:Madprime]]||2022-02-03||[[File:TOEAIX_Expanded_20220203.pdf]]||No medical history related to these analyses.
 
 
|-
 
|-
 
| [[User:Igerg]] || 2022-04-13 || [[File:EXACZL_Additional_20220413.pdf]] || Tested for Lyme several times, all negative
 
| [[User:Igerg]] || 2022-04-13 || [[File:EXACZL_Additional_20220413.pdf]] || Tested for Lyme several times, all negative
 
|-
 
|-
 
| [[User:Madprime]] || 2022-05-27 || [[File:TOEAIX_Additional_20220527.pdf]] ||
 
| [[User:Madprime]] || 2022-05-27 || [[File:TOEAIX_Additional_20220527.pdf]] ||
−
|-
 
−
| [[User:Madprime]] || 2022-08-04 || [[File:TOEAIX_Additional_20220804.pdf]] ||
 
 
|}
 
|}
  
−
 
+
{{Project Queries}}
  
 
[[Category:Projects]]
 
[[Category:Projects]]

Please note that all contributions to Personal Science Wiki are considered to be released under the Creative Commons Attribution-ShareAlike 3.0 Unported (see PersonalScienceWiki:Copyrights for details). If you do not want your writing to be edited mercilessly and redistributed at will, then do not submit it here.
You are also promising us that you wrote this yourself, or copied it from a public domain or similar free resource. Do not submit copyrighted work without permission!

Cancel Editing help (opens in new window)

Template used on this page:

Retrieved from "https://wiki.openhumans.org/wiki/Serimmune_antibody_analysis_results"