Editing Serimmune antibody analysis results

[[File:Serimmunetypicalresults.png|alt=image of a sample result|thumb|Serimmune antibody test results sample.]]
The [https://serimmune.com/covid19study/ Serimmune COVID-19 Study] is a longitudinal research study conducted by the Serimmune company. The study uses the company's "Serum Epitope Repertoire Analysis (SERA) technology" to study antibody responses, especially in the context of COVID-19 vaccination and exposure.


The study returns research-grade results (not intended for diagnostic clinical use) to participants. As described in the [https://serimmune.com/caspio-content/COVID-19-Study-Consent-Form-and-Bill-of-Rights-Preview.pdf study consent document], these results are not clinically validated and not meant to serve as a clinical assay. They are, nevertheless, interesting to look at!

The study is planned to last five years, with blood samples collected every six months. Samples are self-collected by participants using a home collection kit and sent by mail.

= How Serimmune's Technology Works =


According to the company's pre-published<ref>High-resolution mapping and characterization of epitopes in COVID-19 patients

Winston A. Haynes, Kathy Kamath, Joel Bozekowski, Elisabeth Baum-Jones, Melissa Campbell, Arnau Casanovas-Massana, Patrick S. Daugherty, Charles S. Dela Cruz, Abhilash Dhal, Shelli F. Farhadian, Lynn Fitzgibbons, John Fournier, Michael Jhatro, Gregory Jordan, Debra Kessler, Jon Klein, Carolina Lucas, Larry L. Luchsinger, Brian Martinez, Mary C. Muenker, Lauren Pischel, Jack Reifert, Jaymie R. Sawyer, Rebecca Waitz, Elsio A. Wunder Jr., Minlu Zhang, Yale IMPACT Team, Akiko Iwasaki, Albert I. Ko, John C. Shon

medRxiv 2020.11.23.20235002; doi: <nowiki>https://doi.org/10.1101/2020.11.23.20235002</nowiki></ref> research, the technology uses a combination of biochemical assays and a machine learning-based analytics pipeline.

First, they chemically break a blood sample into one million molecules they call the "epitope repertoire". Roughly speaking, this is an approximation of possible ways that antibodies can bond in this individual. 

Next, they compare this individual's epitope with others taken from people with known exposure to specific infections. Theoretically, this is a map to those molecules associated with a particular pathogen. Using a machine learning algorithm trained on epitopes from known infections, the company generates a report to indicate the similarity with this person's epitope.

The gold standard for antibody measurement is a complex process called ELISA (enzyme-linked immunosorbent assay) that involves smudging a bit of sample onto a specially-prepared plate full of proteins known to be associated with the disease. The plate is designed to change color if an antibody to the disease happens to match whatever’s on the plate.

Serimmune claims their test works very well compared to ELISA. It has a high “specificity” (true negative): when they say a sample doesn’t have COVID, they’re almost always right. In fact, when they applied their test to samples taken before the pandemic, every single time they correctly ruled out COVID.

{{Project Infobox|Self researchers=User:Madprime,User:Sprague |Related tools= |Related topics= }}

=SARS-CoV-2 Sample Reports =

[[File:Before_and_after_covid_antibody_results.png|alt=image of results before (one test) and after (two tests) covid infection|thumb|Serimmune results before and after natural covid infection in a previously-vaccinated individual.]]

{| class="wikitable sortable"
|-
! Individual
! Date
! class=unsortable| Report
! Vaccination
! Natural infection
! class=unsortable| Notes
|-
| [[User:Sprague]] || 2021-12-14 || [[File:RichardSpragueSerimmuneCOVID 20211214.pdf]] || Pfizer || No || Pfizer vaccine (two shots, no booster)
|-
| [[User:Madprime]] || 2022-02-03 || [[File:TOEAIX_20220203.pdf]] || Moderna || No || Moderna vaccine (two shots, plus booster).
|-
| [[User:Madprime]] || 2022-05-27 || [[File:TOEAIX_20220527.pdf]] || Moderna || Yes || Covid positive on 2022-05-01.
|-
| [[User:Madprime]] || 2022-08-04 || [[File:TOEAIX_20220804.pdf]] || Moderna || Yes || No additional history.
|-
| [[User:Igerg]] || 2022-04-13 || [[File:EXACZL_20220413.pdf]] || Moderna || No || Moderna vaccine (two shots, plus booster) - chronic spontaneous urticaria following booster
|-
| [[User:EricJain]] || 2022-07-21 || [[File:EricJain-Serimmune-20220721.pdf]] || Pfizer || No || Report includes comparison to 2022-01-20. Vaccinations: 2021-04-21 (Pfizer), 2021-05-12 (Pfizer), 2021-12-08 (Pfizer).
|}


= Other results=

In addition to COVID-19 related antibody analyses, the study shares research analysis of antibodies related to infectious diseases (Lyme Disease, Ehrlichiosis, Anaplasmosis, Babesiosis, Chagas Disease) and autoimmune conditions (Celiac Disease).

{| class="wikitable"
|-
!Individual!!Date!!Report!!Notes
|-
| [[User:Sprague]] || 2021-12-14 ||[[File:RichardSpragueSerimmune_20211214.pdf]] ||
|-
| [[User:Madprime]]||2022-02-03||[[File:TOEAIX_Expanded_20220203.pdf]]||No medical history related to these analyses.
|-
| [[User:Igerg]] || 2022-04-13 || [[File:EXACZL_Additional_20220413.pdf]] || Tested for Lyme several times, all negative
|-
| [[User:Madprime]] || 2022-05-27 || [[File:TOEAIX_Additional_20220527.pdf]] ||
|-
| [[User:Madprime]] || 2022-08-04 || [[File:TOEAIX_Additional_20220804.pdf]] ||
|}



[[Category:Projects]]